Air traffic controllers are striking as part of a national protest against new working conditions introduced by French President Emmanuel Macron.
According to Travel Weekly, up to 75,000 passengers face delayed or cancelled flights across Europe, with at least 550 flights affected.
Flights that are not travelling to or from France could also be affected, as many airlines travel through French air space.
EasyJet cancelled 134 flights yesterday, they confirmed, with ten flights to and from the UK affected.
According to the Independent, British Airways cancelled 36 flights, while Ryanair and Air France have also cancelled flights.
Airports in Paris, Lyon, Marseille and Toulouse are thought to be the most affected, with routes between the UK and France, as well as Portugal and Spain facing cancellations and delays.
One person asked: @easyJet Hi there, we’re booked on a flight tomorrow from Toulouse to Gatwick (mid strike). Will it fly? Or can you transfer us to the flight on Friday? We have a 3 year old and my wife has a hospital operation booked on Sunday.”
Twitter user Ruth said: “Affected by air traffic strikes last year and now faced with cancellation again tomorrow. Furious #frenchairtraffic #strikes #easyjet @easyJet”
Eoin Doyle asked: “@Ryanair hi, flying to Barcelona Girona from Dublin tomorrow – is it likely the flight will be cancelled with the French ATC strikes?”
Another tweeted: “@British_Airways I’m flying on Fri morning, is my flight likely to be cancelled or delayed due to the French air traffic control strike?”